Evidence-informed answers about diagnosis, treatment, co-infections, costs, and expected outcomes from Lyme disease protocols at BioReset.
We use a multi-layered diagnostic approach combining clinical evaluation with advanced laboratory testing. This includes standard two-tier ELISA / Western Blot testing, alongside specialized panels from ArminLabs (Borrelia EliSpot, CD57+ NK cell count), and co-infection screening for Babesia, Bartonella, Ehrlichia, and Anaplasma. We also assess mitochondrial function, inflammatory cytokines, and biotoxin burden to understand the full biological landscape. Clinical history and symptom patterns carry significant diagnostic weight, as no single test is 100% definitive.
Acute Lyme disease occurs within days to weeks of infection and typically responds well to short-course antibiotic therapy when treated early. Persistent or chronic Lyme disease — also called post-treatment Lyme disease syndrome (PTLDS) — involves symptoms that continue for months or years despite standard treatment. At BioReset, we address persistent Lyme by identifying co-infections, immune dysregulation, mitochondrial damage, toxin burden, and microbiome disruption that perpetuate symptoms beyond the initial infection.
Ixodes ticks can transmit multiple pathogens simultaneously. The most common co-infections we detect are Babesiosis (a malaria-like parasite affecting red blood cells), Bartonellosis (causing vascular and neurological symptoms), and Ehrlichiosis / Anaplasmosis (intracellular bacterial infections). Each co-infection requires distinct treatment, and missing them is a leading cause of persistent symptoms. BioReset protocols test and address all detectable co-infections alongside Borrelia.
Early Lyme disease symptoms typically appear 3–30 days after a tick bite and include: erythema migrans (an expanding red rash that may resemble a bull's-eye), fever, chills, fatigue, muscle and joint aches, headache, and swollen lymph nodes. Not everyone develops the classic rash — some rashes are uniformly red or bruise-like. If you suspect a tick bite and experience any combination of these symptoms, seek clinical evaluation promptly. Early treatment yields the highest cure rates.
Treatment duration varies significantly based on disease stage, duration of illness, co-infection burden, and individual biological response. Acute cases may resolve in 4–8 weeks. Persistent or chronic cases typically require 6–12 months of structured, phased treatment — starting with immune modulation and pathogen targeting, followed by mitochondrial restoration, detoxification, and microbiome repair. Patients with heavy co-infection or biotoxin burden may require longer protocols.
Medical ozone is one of our key immunomodulatory tools for chronic Lyme. Ozone major autohemotherapy (MAH) and ozonated saline IVs stimulate immune competence, improve tissue oxygenation, and support the oxidative killing of spirochete bacteria. Ozone also enhances mitochondrial function and reduces systemic inflammation. When combined with antimicrobial protocols, detoxification, and cellular support, ozone significantly accelerates recovery in our Lyme patient population.
The concept of 'cure' depends on disease stage and individual biology. Early Lyme treated promptly has an excellent prognosis. Chronic or persistent Lyme is better understood as a condition of biological restoration — restoring immune balance, mitochondrial energy, detoxification capacity, and microbiome health to a state where symptoms are absent and biological markers normalize. Many of our patients achieve sustained remission with comprehensive, multi-system protocols, though maintenance support is sometimes recommended for complex cases.
Program costs vary based on diagnostic depth and the interventions required. The initial Lyme assessment includes comprehensive tick-borne panels, co-infection screening, immune markers, mitochondrial testing, and biotoxin evaluation — this diagnostic phase is priced individually. Treatment costs depend on whether ozone therapy, IV protocols, peptide therapy, or combination interventions are recommended. During your consultation, Dr. Milios will provide a detailed, personalized treatment plan with transparent pricing before any commitment.
Dr. Milios offers both online video consultations and in-person visits at our Cyprus clinic. The initial comprehensive assessment and certain IV or ozone therapies require in-person presence. However, ongoing consultations, protocol adjustments, and nutritional / supplemental guidance can be delivered remotely. International patients often combine an initial in-person intensive phase with remote follow-up care. We work with patients from across Europe, the Middle East, and beyond.
PTLDS describes the constellation of persistent symptoms — fatigue, joint pain, cognitive issues, sleep disturbance — that continue for 6 months or more after completing standard antibiotic treatment for Lyme disease. At BioReset, we do not view PTLDS as a 'mystery illness.' Instead, we identify the biological drivers that persist after antibiotics: residual co-infections, immune dysregulation, mitochondrial damage, biotoxin accumulation, and disrupted gut ecology. Our protocols target these mechanisms systematically.